• Theoretical investigations of human pancreatic beta-cells: heterogeneous and non-intuitive electrophysiological responses to ion channel antagonists; slow oscillations due to glycolytic oscillations; paracrine signals; gap junction coupling

• Modeling of pancreatic alpha-cells: simulations of electrical activity; micro-RNA mediated effects on electrophysiology and exocytosis; glucose-sensing mechanisms including the roles of SGLT2 and K(ATP)-channels; cAMP-mediated effects downstream of electrical activity

• Intestinal L-cells: glucose sensing converging at electrical activity; spatial modeling of glucose handling, electrical activity, Ca²⁺ dynamics and GLP-1 secretion.

Homepage: www.dei.unipd.it/~pedersen

People: Morten Gram Pedersen (contact person)

• Spatio-temporal modeling of nanoscale Ca²⁺ dynamics near ion channels in pancreatic alpha- and beta-cells and pituitary cells

• Statistical analysis of relations between Ca²⁺ and protein levels at secretory granules and exocytosis

• Modeling of kinetics and molecular control of granule docking and priming prior to exocytosis

Homepage: www.dei.unipd.it/~pedersen

People: Morten Gram Pedersen (contact person)

• Theoretical and computational coupling between cellular dynamics and whole-body patterns of insulin secretion during clinical tests

• Modeling of the interplay between Ca²⁺ dynamics, granule pool depletion, and insulin secretion at the level of single pancreatic islets

• Cellular and inter-islet heterogeneity: importance for dynamic in vivo responses

• Multiscale modeling of glucagon and GLP-1 secretion

Homepage: www.dei.unipd.it/~pedersen

People: Morten Gram Pedersen (contact person), Claudio Cobelli, Chiara Della Man