Short Bio
Francesca Longhin got a Bachelor Degree in Biomedical Engineering (2019) and a Master Degree in Bioengineering (2021) at University of Padova. In October 2021 she started the PhD in Information Engineering. The PhD project aims to the construction of a clinical-purpose software for variant calling and variant functional annotation. It is an industrial PhD project co-financed by the University of Padova and AB ANALITICA, a company mainly dedicated to molecular diagnostics.
Academic Degree
Bachelor's degree in Biomedical Engineering at the University of Padova, Padova, Italy
September 2016 - September 2019
Thesis title: DNA assembly through ProphAsm
Supervisor: Prof. Matteo Comin
Master's Degree in Bioengineering at the University of Padova, Padova, Italy
September 2019 - September 2021
Thesis title: Analysis of the nasopharyngeal microbiota in Sars-Cov-2 positive patients
Supervisor: Prof. Barbara Di Camillo
Appointments
PhD Student in Information Engineering at Department of Information Engineering, University of Padova, Padova, Italy
October 2021 - Today
Research Interests
Francesca Longhin research activity is mainly centered in Bioinformatics and Clinical Genomics. She is currently working on the development of a clinical-use software for analyzing data generated through molecular tests applied to biological samples. Specifically, the software is based on a bioinformatic pipeline to identify genetic mutations which are present in the DNA of tumoral samples and assign them a clinical interpretation. She is also working on a simulator of realistic tumoral samples to be used for validation and optimization of the bioinformatic pipeline. Lastly, she developed a tool for real-time clinical interpretation of mutations that automatically searches the literature for clinical evidence supporting the pathogenicity (or benignity) of the mutation.
Awards
"Best Poster Award" at the 17th Bioinformatics and Computational Biology Conference (BBCC 2022)
Dec, 2022 - Virtual Conference
"Best Poster Award" at the 19th Annual Meeting of the Bioinformatics Italian Society (BITS 2023)
Jun, 2023 - Bari, Italy
Conference contributions
Oral presentation: M. Cappellato, F. Longhin, C. Del Vecchio, G. Brancaccio, M. Bellato, A.M. Cattelan, P. Brun, C. Salaris, I. Castagliuolo, B. Di Camillo. "Uncover a microbiota signature of upper respiratory tract in patients with SARS-CoV-2+" at Bioinformatics and Computational Biology Conference (BBCC) 2021 Meeting
Virtual Conference, December 1-3, 2021
Poster presentation: F. Longhin, M. Cappellato, C. Del Vecchio, G. Brancaccio, M. Bellato, A.M. Cattelan, P. Brun, C. Salaris, I. Castagliuolo, B. Di Camillo. "Uncover a microbiota signature of upper respiratory tract in patients with SARS-CoV-2+" at Annual Meeting of the Bioinformatics Italian Society (BITS) 2022
Verona, Italy, June 27-29, 2022
Oral presentation:F. Longhin. "Interpretative software of data generated by advanced molecular tests based on NGS analytical methods for clinical use" at ARQUS Research Focus Forum on Cancer Research
Padova, Sep 28-30, 2022
Poster presentation: F. Longhin, E. Hazizaj, G. Baruzzo, B. Di Camillo. "Somatic read simulators: how to build a realistic gold standard using data from well-annotated cancer databases" at Annual Meeting of the Bioinformatics and Computational Biology Conference (BBCC) 2022
Virtual Conference, December 13-15, 2022
Poster presentation: F. Longhin, A. Guazzo, E. Longato, D. Boscarino, D. Paladin, N. Ferro, B. Di Camillo. "Manual and automatic identification of ACMG evidence in scientific papers" at Annual Meeting of the Congress of the National Group of Bioengineering (GNB) 2023
Padova, Jun 21-23, 2023
Poster presentation: F. Longhin, E. Hazizaj, G. Baruzzo, B. Di Camillo. "Data-driven meta-simulation of realistic tumoral samples" at Annual Meeting of the Bioinformatic Italian Society (BITS) 2023
Bari, Jun 21-23, 2023
Poster presentation: F. Longhin, E. Hazizaj, G. Baruzzo, B. Di Camillo. "Comprehensive review of tumoral sample simulators: building a realistic gold standard for somatic variant calling validation" at Annual Meeting of the European Conference on Computational Biology (ECCB) 2023
Lyon, Jul 23-27, 2023
Poster presentation: F. Longhin, A. Guazzo, E. Longato, D. Boscarino, D. Paladin, N. Ferro, B. Di Camillo. "Towards automatic ACMG evidence identification for variant interpretation" at Annual Meeting of the European Conference on Computational Biology (ECCB) 2023
Lyon, Jul 23-27, 2023
Poster presentation: F. Longhin, E. Hazizaj, G. Baruzzo, B. Di Camillo. "Leveraging on somatic sample simulators for realistic data-driven generation of tumoral genomes" at Annual Meeting of the Conference on Computational Intelligence Methods for Bioinformatics & Biostatistics (CIBB) 2023
Padova, Sep 6-8, 2023
Poster presentation: F. Longhin, A. Guazzo, E. Longato, D. Boscarino, D. Paladin, N. Ferro, B. Di Camillo. "DAVI: a Dataset for Automatic Variant Interpretation" at Annual Meeting of the Conference and Labs of the Evaluation Forum (CLEF) 2023
Thessaloniki, Sep 18-21, 2023
Role in organization of scientific conferences
Program committee, local committee at 18th Conference on Computational Intelligence Methods for Bioinformatics & Biostatistics (CIBB 2023)
Padova, Italy, Sep 6-8, 2023
Membership
Young-InfoLife group, InfoLife National Laboratory of CINI (role: member)
International Society of Computational Biology - ISCB (role: member)
Referee/Editor activity
Conference referee at "Computational Intelligence Methods for Bioinformatics & Biostatistics (CIBB) 2021"
Granted funding and Principal Investigator (PI) or work package (WP) leader responsibility:
Lender: "project's title"
start-end
Role: ...
PRIN (Call 2017): “Deconstruct and rebuild phenotypes: a multimodal approach toward personalized medicine in ALS (DECIPHER-ALS)”.
2018-2021
Role: Unit PI